Age dependent aneuploidy and telomere length of the human vascular endothelium
H Aviv, MY Khan, J Skurnick, K Okuda, M Kimura… - Atherosclerosis, 2001 - Elsevier
Rationale: aneuploidy and telomere length are two major parameters that have been
associated with cellular senescence in vitro. In order to explore the role of aneuploidy and
telomere length in aging of the human vasculature, we studied these two parameters in
direct preparations of endothelial cells of the human abdominal aorta. Methods: using
fluorescent in situ hybridization on 'touch prep'slides, we evaluated aneuploidy of two
autosomes (chromosomes 6 and 16) and sex chromosomes in non cultured endothelial …
associated with cellular senescence in vitro. In order to explore the role of aneuploidy and
telomere length in aging of the human vasculature, we studied these two parameters in
direct preparations of endothelial cells of the human abdominal aorta. Methods: using
fluorescent in situ hybridization on 'touch prep'slides, we evaluated aneuploidy of two
autosomes (chromosomes 6 and 16) and sex chromosomes in non cultured endothelial …