[HTML][HTML] Osteophytes: relevance and biology
PM Van Der Kraan, WB Van Den Berg - Osteoarthritis and cartilage, 2007 - Elsevier
PM Van Der Kraan, WB Van Den Berg
Osteoarthritis and cartilage, 2007•ElsevierOBJECTIVE: Osteophytes are common features of osteoarthritis. This review summarizes
the current understanding of the clinical relevance and biology of osteophytes. METHOD:
This review summarizes peer-reviewed articles published in the PubMed database before
May 2006. In addition this review is supplemented with own data and theoretical
considerations with regard to osteophyte formation. RESULTS: Osteophytes can contribute
both to the functional properties of affected joints and to clinical relevant symptoms …
the current understanding of the clinical relevance and biology of osteophytes. METHOD:
This review summarizes peer-reviewed articles published in the PubMed database before
May 2006. In addition this review is supplemented with own data and theoretical
considerations with regard to osteophyte formation. RESULTS: Osteophytes can contribute
both to the functional properties of affected joints and to clinical relevant symptoms …
OBJECTIVE
Osteophytes are common features of osteoarthritis. This review summarizes the current understanding of the clinical relevance and biology of osteophytes.
METHOD
This review summarizes peer-reviewed articles published in the PubMed database before May 2006. In addition this review is supplemented with own data and theoretical considerations with regard to osteophyte formation.
RESULTS
Osteophytes can contribute both to the functional properties of affected joints and to clinical relevant symptoms. Osteophyte formation is highly associated with cartilage damage but osteophytes can develop without explicit cartilage damage. Osteophytes are mainly derived from precursor cells in the periosteum and growth factors of the TGFβ superfamily appear to play a crucial role in their induction.
CONCLUSION
Osteophyte formation is an integral component of OA pathogenesis and understanding the biology of osteophyte formation can give insights in the disturbed homeostasis in OA joints.
Elsevier
