[HTML][HTML] CCL8 and the immune control of cytomegalovirus in organ transplant recipients
LF Lisboa, A Egli, J Fairbanks, D O'Shea… - American Journal of …, 2015 - Elsevier
Monitoring of cytomegalovirus cell-mediated immunity is a promising tool for the refinement
of preventative and therapeutic strategies posttransplantation. Typically, the interferon-γ
response to T cell stimulation is measured. We evaluated a broad range of cytokine and
chemokines to better characterize the ex vivo host-response to CMV peptide stimulation. In a
cohort of CMV viremic organ transplant recipients, chemokine expression—specifically
CCL8 (AUC 0.849 95% CI 0.721–0.978; p= 0.003) and CXCL10 (AUC 0.841, 95% CI 0.707 …
of preventative and therapeutic strategies posttransplantation. Typically, the interferon-γ
response to T cell stimulation is measured. We evaluated a broad range of cytokine and
chemokines to better characterize the ex vivo host-response to CMV peptide stimulation. In a
cohort of CMV viremic organ transplant recipients, chemokine expression—specifically
CCL8 (AUC 0.849 95% CI 0.721–0.978; p= 0.003) and CXCL10 (AUC 0.841, 95% CI 0.707 …