[HTML][HTML] The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor ζ …
MA Purbhoo, JM Boulter, DA Price, AL Vuidepot… - Journal of Biological …, 2001 - ASBMB
Recognition of antigen by cytotoxic T lymphocytes (CTL) is determined by interaction of both
the T cell receptor and its CD8 coreceptor with peptide-major histocompatibility complex
(pMHC) class I molecules. We examine the relative roles of these receptors in the activation
of human CTL using mutations in MHC class I designed to diminish or abrogate the
CD8/pMHC interaction. We use surface plasmon resonance to determine that point mutation
of the α3 loop of HLA A2 abrogates the CD8/pMHC interaction without affecting the affinity of …
the T cell receptor and its CD8 coreceptor with peptide-major histocompatibility complex
(pMHC) class I molecules. We examine the relative roles of these receptors in the activation
of human CTL using mutations in MHC class I designed to diminish or abrogate the
CD8/pMHC interaction. We use surface plasmon resonance to determine that point mutation
of the α3 loop of HLA A2 abrogates the CD8/pMHC interaction without affecting the affinity of …