[HTML][HTML] T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting
Altered peptide antigens that enhance T-cell immunogenicity have been used to improve
peptide-based vaccination for a range of diseases. Although this strategy can prime T-cell
responses of greater magnitude, the efficacy of constituent T-cell clonotypes within the
primed population can be poor. To overcome this limitation, we isolated a CD8+ T-cell clone
(MEL5) with an enhanced ability to recognize the HLA A* 0201-Melan A 27–35 (HLA A*
0201-AAGIGILTV) antigen expressed on the surface of malignant melanoma cells. We used …
peptide-based vaccination for a range of diseases. Although this strategy can prime T-cell
responses of greater magnitude, the efficacy of constituent T-cell clonotypes within the
primed population can be poor. To overcome this limitation, we isolated a CD8+ T-cell clone
(MEL5) with an enhanced ability to recognize the HLA A* 0201-Melan A 27–35 (HLA A*
0201-AAGIGILTV) antigen expressed on the surface of malignant melanoma cells. We used …