[HTML][HTML] More than one reason to rethink the use of peptides in vaccine design
Nature reviews Drug discovery, 2007•nature.com
The use of peptides as therapeutics is experiencing renewed enthusiasm owing to
advances in delivery, stability and design. Moreover, there is a growing emphasis on the use
of peptides in vaccine design as insights into tissue-specific processing of the immunogenic
epitopes of proteins and the discovery of unusually long cytotoxic T-lymphocyte epitopes
broaden the range of targets and give clues to enhancing peptide immunogenicity. Peptides
can also be synthesized with known post-translational modifications and/or deliberately …
advances in delivery, stability and design. Moreover, there is a growing emphasis on the use
of peptides in vaccine design as insights into tissue-specific processing of the immunogenic
epitopes of proteins and the discovery of unusually long cytotoxic T-lymphocyte epitopes
broaden the range of targets and give clues to enhancing peptide immunogenicity. Peptides
can also be synthesized with known post-translational modifications and/or deliberately …
Abstract
The use of peptides as therapeutics is experiencing renewed enthusiasm owing to advances in delivery, stability and design. Moreover, there is a growing emphasis on the use of peptides in vaccine design as insights into tissue-specific processing of the immunogenic epitopes of proteins and the discovery of unusually long cytotoxic T-lymphocyte epitopes broaden the range of targets and give clues to enhancing peptide immunogenicity. Peptides can also be synthesized with known post-translational modifications and/or deliberately introduced protease-resistant peptide bonds to regulate their processing independent of tissue-specific proteolysis and to stabilize these compounds in vivo. We discuss the potential of peptide-based vaccines for the treatment of chronic viral diseases and cancer, and review recent developments in the field of peptide-based vaccines.
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