Obesity, inflammation, and atherosclerosis

VZ Rocha, P Libby - Nature Reviews Cardiology, 2009 - nature.com
VZ Rocha, P Libby
Nature Reviews Cardiology, 2009nature.com
Understanding of the pathophysiology of atherogenesis has evolved substantially during the
last few decades. Atherosclerosis was once identified as a lipid-storage disease, but is now
recognized as a subacute inflammatory condition of the vessel wall, characterized by
infiltration of macrophages and T cells, which interact with one another and with cells of the
arterial wall. The pathological mechanisms of obesity recapitulate many features of the
inflammatory processes at work in atherosclerosis. Our current appreciation of the …
Abstract
Understanding of the pathophysiology of atherogenesis has evolved substantially during the last few decades. Atherosclerosis was once identified as a lipid-storage disease, but is now recognized as a subacute inflammatory condition of the vessel wall, characterized by infiltration of macrophages and T cells, which interact with one another and with cells of the arterial wall. The pathological mechanisms of obesity recapitulate many features of the inflammatory processes at work in atherosclerosis. Our current appreciation of the similarities between obesity and atherosclerosis has already fostered innovations for the diagnosis, prognosis, and prevention of these two conditions.
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