Remodeling chromatin for senescence
PD Adams - Aging cell, 2007 - Wiley Online Library
PD Adams
Aging cell, 2007•Wiley Online LibraryCellular senescence is an irreversible proliferation arrest that contributes to tumor
suppression and, perhaps, tissue aging. Senescence is frequently accompanied by an
increase in nuclear heterochromatin, which is thought to promote proliferation arrest. In this
issue, Medrano and co‐workers describe new insights into the protein complexes that
regulate these changes in chromatin structure.
suppression and, perhaps, tissue aging. Senescence is frequently accompanied by an
increase in nuclear heterochromatin, which is thought to promote proliferation arrest. In this
issue, Medrano and co‐workers describe new insights into the protein complexes that
regulate these changes in chromatin structure.
Summary
Cellular senescence is an irreversible proliferation arrest that contributes to tumor suppression and, perhaps, tissue aging. Senescence is frequently accompanied by an increase in nuclear heterochromatin, which is thought to promote proliferation arrest. In this issue, Medrano and co‐workers describe new insights into the protein complexes that regulate these changes in chromatin structure.
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