[HTML][HTML] LRP1 protein deficiency exacerbates palmitate-induced steatosis and toxicity in hepatocytes
AN Hamlin, JE Basford, A Jaeschke, DY Hui - Journal of Biological …, 2016 - ASBMB
LRP1 (LDL receptor-related protein-1) is a ubiquitous receptor with both cell signaling and
ligand endocytosis properties. In the liver, LRP1 serves as a chylomicron remnant receptor
and also participates in the transport of extracellular cathepsin D to the lysosome for
prosaposin activation. The current study showed that in comparison with wild type mice,
hepatocyte-specific LRP1 knock-out (hLrp1−/−) mice were more susceptible to fasting-
induced lipid accumulation in the liver. Primary hepatocytes isolated from hLrp1−/− mice …
ligand endocytosis properties. In the liver, LRP1 serves as a chylomicron remnant receptor
and also participates in the transport of extracellular cathepsin D to the lysosome for
prosaposin activation. The current study showed that in comparison with wild type mice,
hepatocyte-specific LRP1 knock-out (hLrp1−/−) mice were more susceptible to fasting-
induced lipid accumulation in the liver. Primary hepatocytes isolated from hLrp1−/− mice …