[HTML][HTML] The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65
A Kinoshita, T Shah, MM Tangredi… - Journal of Biological …, 2003 - ASBMB
Low density lipoprotein-related protein (LRP) is a transmembrane receptor, localized mainly
in hepatocytes, fibroblasts, and neurons. It is implicated in diverse biological processes both
as an endocytic receptor and as a signaling molecule. Recent reports show that LRP
undergoes sequential proteolytic cleavage in the ectodomain and transmembrane domain.
The latter cleavage, mediated by the Alzheimer-related γ-secretase activity that also cleaves
amyloid precursor protein (APP) and Notch, results in the release of the LRP cytoplasmic …
in hepatocytes, fibroblasts, and neurons. It is implicated in diverse biological processes both
as an endocytic receptor and as a signaling molecule. Recent reports show that LRP
undergoes sequential proteolytic cleavage in the ectodomain and transmembrane domain.
The latter cleavage, mediated by the Alzheimer-related γ-secretase activity that also cleaves
amyloid precursor protein (APP) and Notch, results in the release of the LRP cytoplasmic …