Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions

R Virmani, FD Kolodgie, AP Burke, A Farb… - … , and vascular biology, 2000 - Am Heart Assoc
R Virmani, FD Kolodgie, AP Burke, A Farb, SM Schwartz
Arteriosclerosis, thrombosis, and vascular biology, 2000Am Heart Assoc
This review will reconsider the current paradigm for understanding the critical, final steps in
the progression of atherosclerotic lesions. That scheme, largely an outgrowth of
observations of autopsy tissues by Davies and colleagues, 1, 2 asserts that the cause of
death in atherosclerotic coronary artery disease is rupture of an advanced atherosclerotic
lesion. Although this assumption may be partially true, recent autopsy studies suggest that it
is incomplete.
This review will reconsider the current paradigm for understanding the critical, final steps in the progression of atherosclerotic lesions. That scheme, largely an outgrowth of observations of autopsy tissues by Davies and colleagues, 1, 2 asserts that the cause of death in atherosclerotic coronary artery disease is rupture of an advanced atherosclerotic lesion. Although this assumption may be partially true, recent autopsy studies suggest that it is incomplete.
Am Heart Assoc