Hepcidin-ferroportin axis controls toll-like receptor 4 dependent macrophage inflammatory responses in human atherosclerotic plaques
A Habib, R Polavarapu, V Karmali, L Guo, R Van Dam… - Atherosclerosis, 2015 - Elsevier
Abstract Objectives Toll-like Receptor 4 (TLR4) is implicated in modulating inflammatory
cytokines though its role in atherosclerosis remains uncertain. We have recently described a
non-foam cell macrophage phenotype driven by ingestion of hemoglobin: haptoglobin
complexes (HH), via the scavenger receptor CD163, characterized by reduced inflammatory
cytokine production. In this study, we examined the role of iron metabolism in modulating
TLR4 signaling in these cells. Methods and results Areas in human atherosclerotic plaque …
cytokines though its role in atherosclerosis remains uncertain. We have recently described a
non-foam cell macrophage phenotype driven by ingestion of hemoglobin: haptoglobin
complexes (HH), via the scavenger receptor CD163, characterized by reduced inflammatory
cytokine production. In this study, we examined the role of iron metabolism in modulating
TLR4 signaling in these cells. Methods and results Areas in human atherosclerotic plaque …