Mechanisms of sudden unexplained death in epilepsy
AM Goldman - Current opinion in neurology, 2015 - journals.lww.com
AM Goldman
Current opinion in neurology, 2015•journals.lww.comExtensive clinical and experimental work has established a rationale for the conceptual
thinking about SUDEP mechanisms. The application of the global molecular profiling will be
invaluable in unraveling the individually unique genomic complexities and interactions that
underlie the physiological signature of each patient. At the same time, sophisticated model
systems will be critical in the iterative translation of human genetics, physiology,
pharmacological interventions, and in testing preventive interventions.
thinking about SUDEP mechanisms. The application of the global molecular profiling will be
invaluable in unraveling the individually unique genomic complexities and interactions that
underlie the physiological signature of each patient. At the same time, sophisticated model
systems will be critical in the iterative translation of human genetics, physiology,
pharmacological interventions, and in testing preventive interventions.
Summary
Extensive clinical and experimental work has established a rationale for the conceptual thinking about SUDEP mechanisms. The application of the global molecular profiling will be invaluable in unraveling the individually unique genomic complexities and interactions that underlie the physiological signature of each patient. At the same time, sophisticated model systems will be critical in the iterative translation of human genetics, physiology, pharmacological interventions, and in testing preventive interventions.
Lippincott Williams & Wilkins