Structure and Regulation of Voltage-Gated Ca2+ Channels
WA Catterall - Annual review of cell and developmental biology, 2000 - annualreviews.org
▪ Abstract Voltage-gated Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents
designated L-, N-, P-, Q-, R-, and T-type. The high-voltage-activated Ca2+ channels that
have been characterized biochemically are complexes of a pore-forming α1 subunit of∼
190–250 kDa; a transmembrane, disulfide-linked complex of α2 and δ subunits; an
intracellular β subunit; and in some cases a transmembrane γ subunit. Ten α1 subunits, four …
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents
designated L-, N-, P-, Q-, R-, and T-type. The high-voltage-activated Ca2+ channels that
have been characterized biochemically are complexes of a pore-forming α1 subunit of∼
190–250 kDa; a transmembrane, disulfide-linked complex of α2 and δ subunits; an
intracellular β subunit; and in some cases a transmembrane γ subunit. Ten α1 subunits, four …