Regional heterogeneity of lobar ventilation in asthma using hyperpolarized helium-3 MRI
Rationale and Objectives To determine lobar ventilation patterns in asthmatic lungs with
hyperpolarized 3 He magnetic resonance imaging (HP 3 He MRI). Materials and Methods
Eighty-two subjects (14 normal, 48 mild-to-moderate asthma, and 20 severe asthma)
underwent HP 3 He MRI, computed tomography (CT), and pulmonary function testing. After
registering proton to 3 He images, we segmented the lungs from proton MRI and further
segmented the five lung lobes (right upper lobe [RUL], right middle lobe [RML], and right …
hyperpolarized 3 He magnetic resonance imaging (HP 3 He MRI). Materials and Methods
Eighty-two subjects (14 normal, 48 mild-to-moderate asthma, and 20 severe asthma)
underwent HP 3 He MRI, computed tomography (CT), and pulmonary function testing. After
registering proton to 3 He images, we segmented the lungs from proton MRI and further
segmented the five lung lobes (right upper lobe [RUL], right middle lobe [RML], and right …