Contributions of Fas-Fas ligand interactions to the pathogenesis of mouse hepatitis virus in the central nervous system
B Parra, MT Lin, SA Stohlman, CC Bergmann… - Journal of …, 2000 - Am Soc Microbiol
Journal of Virology, 2000•Am Soc Microbiol
The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice
suggested that Fas-mediated cytotoxicity may be required during viral clearance after the
loss of perforin-mediated cytotoxicity. The absence of both Fas-and perforin-mediated
cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic
pathways to control virus replication.
suggested that Fas-mediated cytotoxicity may be required during viral clearance after the
loss of perforin-mediated cytotoxicity. The absence of both Fas-and perforin-mediated
cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic
pathways to control virus replication.
Abstract
The pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested that Fas-mediated cytotoxicity may be required during viral clearance after the loss of perforin-mediated cytotoxicity. The absence of both Fas- and perforin-mediated cytolysis resulted in an uncontrolled infection, suggesting a redundancy of cytolytic pathways to control virus replication.
American Society for Microbiology