The contribution of bone to whole-organism physiology

G Karsenty, M Ferron - Nature, 2012 - nature.com
Nature, 2012nature.com
The mouse genetic revolution has shown repeatedly that most organs have more functions
than expected. This has led to the realization that, in addition to a molecular and cellular
approach, there is a need for a whole-organism study of physiology. The skeleton is an
example of how a whole-organism approach to physiology can broaden the functions of a
given organ, reveal connections of this organ with others such as the brain, pancreas and
gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple …
Abstract
The mouse genetic revolution has shown repeatedly that most organs have more functions than expected. This has led to the realization that, in addition to a molecular and cellular approach, there is a need for a whole-organism study of physiology. The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
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