Molecular regulation of stem cell quiescence

TH Cheung, TA Rando - Nature reviews Molecular cell biology, 2013 - nature.com
Nature reviews Molecular cell biology, 2013nature.com
Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of
time. This state, which is reversible, has long been viewed as dormant and with minimal
basal activity. Recent advances in adult stem cell isolation have provided insights into the
epigenetic, transcriptional and post-transcriptional control of quiescence and suggest that
quiescence is an actively maintained state in which signalling pathways are involved in
maintaining a poised state that allows rapid activation. Deciphering the molecular …
Abstract
Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of time. This state, which is reversible, has long been viewed as dormant and with minimal basal activity. Recent advances in adult stem cell isolation have provided insights into the epigenetic, transcriptional and post-transcriptional control of quiescence and suggest that quiescence is an actively maintained state in which signalling pathways are involved in maintaining a poised state that allows rapid activation. Deciphering the molecular mechanisms regulating adult stem cell quiescence will increase our understanding of tissue regeneration mechanisms and how they are dysregulated in pathological conditions and in ageing.
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