[HTML][HTML] Regulation of voltage-dependent calcium channels by RGK proteins
T Yang, HM Colecraft - Biochimica et Biophysica Acta (BBA)-Biomembranes, 2013 - Elsevier
T Yang, HM Colecraft
Biochimica et Biophysica Acta (BBA)-Biomembranes, 2013•ElsevierRGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include
four members—Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and
are the most potent known intracellular inhibitors of high-voltage-activated Ca2+ (CaV1 and
CaV2) channels. Here, we review and discuss the evidence in the literature regarding the
functional mechanisms, structural determinants, physiological role, and potential practical
applications of RGK-mediated inhibition of CaV1/CaV2 channels. This article is part of a …
four members—Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and
are the most potent known intracellular inhibitors of high-voltage-activated Ca2+ (CaV1 and
CaV2) channels. Here, we review and discuss the evidence in the literature regarding the
functional mechanisms, structural determinants, physiological role, and potential practical
applications of RGK-mediated inhibition of CaV1/CaV2 channels. This article is part of a …
RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include four members — Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and are the most potent known intracellular inhibitors of high-voltage-activated Ca2+ (CaV1 and CaV2) channels. Here, we review and discuss the evidence in the literature regarding the functional mechanisms, structural determinants, physiological role, and potential practical applications of RGK-mediated inhibition of CaV1/CaV2 channels. This article is part of a Special Issue entitled: Calcium channels.
Elsevier