[HTML][HTML] Fibrinogen gamma-A chain precursor in CSF: a candidate biomarker for Alzheimer's disease
JW Lee, H Namkoong, HK Kim, S Kim, DW Hwang… - BMC neurology, 2007 - Springer
JW Lee, H Namkoong, HK Kim, S Kim, DW Hwang, HR Na, SA Ha, JR Kim, JW Kim
BMC neurology, 2007•SpringerBackground Cerebrospinal fluid (CSF) may be valuable for exploring protein markers for the
diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to
slow progression, holds hope for aging populations with increased average lifespan. The
aim of the present study was to investigate candidate CSF biological markers in patients with
mild cognitive impairment (MCI) and AD and compare them with age-matched normal
control subjects. Methods We applied proteomics approaches to analyze CSF samples …
diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to
slow progression, holds hope for aging populations with increased average lifespan. The
aim of the present study was to investigate candidate CSF biological markers in patients with
mild cognitive impairment (MCI) and AD and compare them with age-matched normal
control subjects. Methods We applied proteomics approaches to analyze CSF samples …
Background
Cerebrospinal fluid (CSF) may be valuable for exploring protein markers for the diagnosis of Alzheimer's disease (AD). The prospect of early detection and treatment, to slow progression, holds hope for aging populations with increased average lifespan. The aim of the present study was to investigate candidate CSF biological markers in patients with mild cognitive impairment (MCI) and AD and compare them with age-matched normal control subjects.
Methods
We applied proteomics approaches to analyze CSF samples derived from 27 patients with AD, 3 subjects with MCI and 30 controls. The AD group was subdivided into three groups by clinical severity according to clinical dementia rating (CDR), a well known clinical scale for dementia.
Results
We demonstrated an elevated level of fibrinogen gamma-A chain precursor protein in CSF from patients with mild cognitive impairment and AD compared to the age-matched normal subjects. Moreover, its expression was more prominent in the AD group than in the MCI and correlated with disease severity and progression. In contrast, fibrinogen gamma-A chain precursor protein was detected very low in the age-matched normal group.
Conclusion
These findings suggest that the CSF level of fibrinogen gamma-A chain precursor may be a candidate biomarker for AD.
Springer