Commentary on “Tissue-specific mutagenesis by N-butyl-N-(4-hydroxybutyl) nitrosamine as the basis for urothelial cell carcinogenesis.” He Z, Kosinska W, Zhao ZL …
DS Scherr - Urologic Oncology: Seminars and Original …, 2014 - Elsevier
Bladder cancer is one of the few cancers that have been linked to carcinogens in the
environment and tobacco smoke. Of the carcinogens tested in mouse chemical
carcinogenesis models, N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) is one that
reproducibly causes high-grade, invasive cancers in the urinary bladder, but not in any other
tissues. However, the basis for such a high-level tissue-specificity has not been explored.
Using mutagenesis in lacI (Big Blue™) mice, we show here that BBN is a potent mutagen …
environment and tobacco smoke. Of the carcinogens tested in mouse chemical
carcinogenesis models, N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) is one that
reproducibly causes high-grade, invasive cancers in the urinary bladder, but not in any other
tissues. However, the basis for such a high-level tissue-specificity has not been explored.
Using mutagenesis in lacI (Big Blue™) mice, we show here that BBN is a potent mutagen …