Uric acid and fructose: potential biological mechanisms

MA Lanaspa, E Tapia, V Soto, Y Sautin… - Seminars in …, 2011 - Elsevier
Excessive fructose consumption is associated with the development of metabolic syndrome
and type II diabetes. Both conditions are well-known risk factors for cardiovascular and renal
diseases. Uric acid synthesis is linked biochemically to fructose metabolism, thus the
widespread consumption of this monosaccharide has been related to steady increasing
levels of serum uric acid during the past few decades. Recent evidence has suggested that
uric acid may act as a cardiorenal toxin. In this regard, experimental studies have suggested …