Background: Concerns have been raised about the concurrent temporal trend between
simple sugar intakes, especially of fructose or high-fructose corn syrup (HFCS), and rates of
nonalcoholic fatty liver disease (NAFLD) in the United States. Objective: We examined the
effect of different amounts and forms of dietary fructose on the incidence or prevalence of
NAFLD and indexes of liver health in humans. Design: We conducted a systematic review of
English-language, human studies of any design in children and adults with low to no alcohol …