pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity
WD Kohn, R Micanovic, SL Myers, AM Vick, SD Kahl… - Peptides, 2007 - Elsevier
A long-acting (basal) insulin capable of delivering flat, sustained, reproducible glycemic
control with once daily administration represents an improvement in the treatment paradigm
for both type 1 and type 2 diabetes. Optimization of insulin pharmacodynamics is achievable
through structural modification, but often at the expense of alterations in receptor affinity and
selectivity. A series of isoelectric point (pI)-shifted insulin analogs based on the human
insulin sequence or the GlyA21 acid stable variant were prepared by semi-synthetic …
control with once daily administration represents an improvement in the treatment paradigm
for both type 1 and type 2 diabetes. Optimization of insulin pharmacodynamics is achievable
through structural modification, but often at the expense of alterations in receptor affinity and
selectivity. A series of isoelectric point (pI)-shifted insulin analogs based on the human
insulin sequence or the GlyA21 acid stable variant were prepared by semi-synthetic …