Mechanism of DNA double-strand break repair by non-homologous end joining
ML Hefferin, AE Tomkinson - DNA repair, 2005 - Elsevier
The repair of DNA double-strand breaks (DSBs) is critical for maintaining genome stability.
Although the non-homologous end joining (NHEJ) pathway frequently results in minor
changes in DNA sequence at the break site and occasionally the joining of previously
unlinked DNA molecules, it is a major contributor to cell survival following exposure of
mammalian cells to agents that cause DSBs. This repair mechanism is conserved in lower
eukaryotes and in some prokaryotes although the majority of DSBs are repaired by …
Although the non-homologous end joining (NHEJ) pathway frequently results in minor
changes in DNA sequence at the break site and occasionally the joining of previously
unlinked DNA molecules, it is a major contributor to cell survival following exposure of
mammalian cells to agents that cause DSBs. This repair mechanism is conserved in lower
eukaryotes and in some prokaryotes although the majority of DSBs are repaired by …