DNA double-strand break repair pathway choice and cancer
T Aparicio, R Baer, J Gautier - DNA repair, 2014 - Elsevier
Since DNA double-strand breaks (DSBs) contribute to the genomic instability that drives
cancer development, DSB repair pathways serve as important mechanisms for tumor
suppression. Thus, genetic lesions, such as BRCA1 and BRCA2 mutations, that disrupt DSB
repair are often associated with cancer susceptibility. In addition, recent evidence suggests
that DSB “mis-repair”, in which DSBs are resolved by an inappropriate repair pathway, can
also promote genomic instability and presumably tumorigenesis. This notion has gained …
cancer development, DSB repair pathways serve as important mechanisms for tumor
suppression. Thus, genetic lesions, such as BRCA1 and BRCA2 mutations, that disrupt DSB
repair are often associated with cancer susceptibility. In addition, recent evidence suggests
that DSB “mis-repair”, in which DSBs are resolved by an inappropriate repair pathway, can
also promote genomic instability and presumably tumorigenesis. This notion has gained …