[HTML][HTML] Differential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases
S Latour, LML Chow, A Veillette - Journal of Biological Chemistry, 1996 - ASBMB
Syk and Zap-70 are related protein-tyrosine kinases implicated in antigen and Fc receptor
signaling. While Zap-70 is restricted to T-cells and natural killer cells, Syk accumulates in B-
cells, mast cells, platelets, and immature T-cells. In addition, we found that an isoform of Syk
(SykB), which carries a 23-amino acid deletion in the" linker" region, is prominently
expressed in bone marrow. To better understand the relative impact of Syk, SykB, and Zap-
70 on signal transduction, we compared their intrinsic enzymatic properties in transiently …
signaling. While Zap-70 is restricted to T-cells and natural killer cells, Syk accumulates in B-
cells, mast cells, platelets, and immature T-cells. In addition, we found that an isoform of Syk
(SykB), which carries a 23-amino acid deletion in the" linker" region, is prominently
expressed in bone marrow. To better understand the relative impact of Syk, SykB, and Zap-
70 on signal transduction, we compared their intrinsic enzymatic properties in transiently …