[HTML][HTML] Inhibition of myogenesis by multiple cyclin-Cdk complexes: coordinate regulation of myogenesis and cell cycle activity at the level of E2F
K Guo, K Walsh - Journal of Biological Chemistry, 1997 - ASBMB
During skeletal myogenesis, cell cycle withdrawal accompanies the expression of the
contractile phenotype. Here we show that ectopic expression of each D-type cyclin is
sufficient to inhibit the transcriptional activation of the muscle-specific creatine kinase (MCK)
gene. In contrast, ectopic expression of cyclin A or cyclin E inhibits MCK expression only
when they are co-expressed with their catalytic partner cyclin-dependent kinase 2 (Cdk2).
For each of these conditions, myogenic transcriptional inhibition is reversed by the ectopic …
contractile phenotype. Here we show that ectopic expression of each D-type cyclin is
sufficient to inhibit the transcriptional activation of the muscle-specific creatine kinase (MCK)
gene. In contrast, ectopic expression of cyclin A or cyclin E inhibits MCK expression only
when they are co-expressed with their catalytic partner cyclin-dependent kinase 2 (Cdk2).
For each of these conditions, myogenic transcriptional inhibition is reversed by the ectopic …