[PDF][PDF] EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate …
IM Bachmann, OJ Halvorsen, K Collett, IM Stefansson… - J Clin Oncol, 2006 - academia.edu
IM Bachmann, OJ Halvorsen, K Collett, IM Stefansson, O Straume, SA Haukaas…
J Clin Oncol, 2006•academia.eduPurpose EZH2 is a member of the polycomb group of genes and important in cell cycle
regulation. Increased expression of EZH2 has been associated previously with invasive
growth and aggressive clinical behavior in prostate and breast cancer, but the relationship
with tumor cell proliferation has not been examined in human tumors. The purpose of this
study was to validate previous findings in a population-based setting, also including tumors
that have not been studied previously.
regulation. Increased expression of EZH2 has been associated previously with invasive
growth and aggressive clinical behavior in prostate and breast cancer, but the relationship
with tumor cell proliferation has not been examined in human tumors. The purpose of this
study was to validate previous findings in a population-based setting, also including tumors
that have not been studied previously.
Purpose
EZH2 is a member of the polycomb group of genes and important in cell cycle regulation. Increased expression of EZH2 has been associated previously with invasive growth and aggressive clinical behavior in prostate and breast cancer, but the relationship with tumor cell proliferation has not been examined in human tumors. The purpose of this study was to validate previous findings in a population-based setting, also including tumors that have not been studied previously.
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