Endoplasmic reticulum stress in nonalcoholic fatty liver disease
MJ Pagliassotti - Annual review of nutrition, 2012 - annualreviews.org
The underlying causes of nonalcoholic fatty liver disease are unclear, although recent
evidence has implicated the endoplasmic reticulum in both the development of steatosis and
progression to nonalcoholic steatohepatitis. Disruption of endoplasmic reticulum
homeostasis, often termed ER stress, has been observed in liver and adipose tissue of
humans with nonalcoholic fatty liver disease and/or obesity. Importantly, the signaling
pathway activated by disruption of endoplasmic reticulum homeostasis, the unfolded protein …
evidence has implicated the endoplasmic reticulum in both the development of steatosis and
progression to nonalcoholic steatohepatitis. Disruption of endoplasmic reticulum
homeostasis, often termed ER stress, has been observed in liver and adipose tissue of
humans with nonalcoholic fatty liver disease and/or obesity. Importantly, the signaling
pathway activated by disruption of endoplasmic reticulum homeostasis, the unfolded protein …