Myeloproliferative neoplasms: a contemporary review
A Tefferi, A Pardanani - JAMA oncology, 2015 - jamanetwork.com
Polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF)
constitute theBCR-ABL1–negative myeloproliferative neoplasms and are characterized by
mutually exclusive Janus kinase 2 (JAK2), calreticulin (CALR), and myeloproliferative
leukemia virus oncogene (MPL) mutations; respective frequencies of these mutations are
approximately 95%, 0%, and 0% in PV, 60%, 20%, and 3% in ET, and 60%, 25%, and 7% in
PMF. These mutations might be accompanied by other mutations that are less specific to …
constitute theBCR-ABL1–negative myeloproliferative neoplasms and are characterized by
mutually exclusive Janus kinase 2 (JAK2), calreticulin (CALR), and myeloproliferative
leukemia virus oncogene (MPL) mutations; respective frequencies of these mutations are
approximately 95%, 0%, and 0% in PV, 60%, 20%, and 3% in ET, and 60%, 25%, and 7% in
PMF. These mutations might be accompanied by other mutations that are less specific to …