Attenuated liver progenitor (oval) cell and fibrogenic responses to the choline deficient, ethionine supplemented diet in the BALB/c inbred strain of mice
B Knight, B Akhurst, VB Matthews, RG Ruddell… - Journal of …, 2007 - Elsevier
BACKGROUND/AIMS: Liver regeneration following chronic injury is associated with
inflammation, the proliferation of liver progenitor (oval) cells and fibrosis. Previous studies
identified interferon-gamma as a key mediator of oval cell proliferation. Interferon-γ is known
to regulate Th1 cell activities during immune challenge. Therefore, we hypothesised that
progenitor cell-mediated regeneration is associated with a Th1 immune response.
METHODS: C57Bl/6 (normal Th1 response) and BALB/c mice (deficient in Th1 signalling) …
inflammation, the proliferation of liver progenitor (oval) cells and fibrosis. Previous studies
identified interferon-gamma as a key mediator of oval cell proliferation. Interferon-γ is known
to regulate Th1 cell activities during immune challenge. Therefore, we hypothesised that
progenitor cell-mediated regeneration is associated with a Th1 immune response.
METHODS: C57Bl/6 (normal Th1 response) and BALB/c mice (deficient in Th1 signalling) …