Ethanol-induced liver fibrosis in rats fed high fat diet
H Tsukamoto, SJ Towner, LM Clofalo, SW French - Hepatology, 1986 - journals.lww.com
Severe hepatic steatosis and focal necrosis of hepatocytes have previously been induced in
rats by continuous intragastric infusion of ethanol and a diet containing only 5% fat as a per
cent of total calories as reported by us previously. Since the ethanol diet fed ad libitum with
such a low level of fat has previously failed to produce alcoholic fatty liver, continuously high
blood alcohol levels achieved in this model appeared to be key in induction of the
progressive pathologic lesions in the liver. In the current study, effects of increased fat intake …
rats by continuous intragastric infusion of ethanol and a diet containing only 5% fat as a per
cent of total calories as reported by us previously. Since the ethanol diet fed ad libitum with
such a low level of fat has previously failed to produce alcoholic fatty liver, continuously high
blood alcohol levels achieved in this model appeared to be key in induction of the
progressive pathologic lesions in the liver. In the current study, effects of increased fat intake …