Tissue inhibitor of metalloproteinase–1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and …
JP Iredale, RC Benyon, MJ Arthur, WF Ferris… - Hepatology, 1996 - journals.lww.com
Liver fibrosis results from a relative imbalance between synthesis and degradation of matrix
proteins. We have previously described release of the protein collagenase inhibitor, tissue
inhibitor of metalloproteinase–1 (TIMP–1), by culture–activated human hepatic stellate cells
(HSCs). In this study, we have investigated the relative expression of TIMP–1 and interstitial
collagenase in culture–activated rat HSCs and rat models of liver injury and fibrosis. The
complementary DNA (cDNA) for rat TIMP–1 was obtained by homology polymerase chain …
proteins. We have previously described release of the protein collagenase inhibitor, tissue
inhibitor of metalloproteinase–1 (TIMP–1), by culture–activated human hepatic stellate cells
(HSCs). In this study, we have investigated the relative expression of TIMP–1 and interstitial
collagenase in culture–activated rat HSCs and rat models of liver injury and fibrosis. The
complementary DNA (cDNA) for rat TIMP–1 was obtained by homology polymerase chain …