Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum
FL Jayes, B Liu, FT Moutos, M Kuchibhatla… - American journal of …, 2016 - Elsevier
Background Uterine fibroids are a significant health problem. These common benign tumors
occur in 70–80% of women before age 50 years and often cause bleeding and pain and can
interfere considerably with daily life. Current treatment options are limited. Fibroids contain
substantial amounts of altered and disordered collagens, which contribute to their bulk.
Targeting these collagens directly presents a novel treatment approach. Objectives We
sought to test the hypothesis that a highly purified collagenase Clostridium histolyticum will …
occur in 70–80% of women before age 50 years and often cause bleeding and pain and can
interfere considerably with daily life. Current treatment options are limited. Fibroids contain
substantial amounts of altered and disordered collagens, which contribute to their bulk.
Targeting these collagens directly presents a novel treatment approach. Objectives We
sought to test the hypothesis that a highly purified collagenase Clostridium histolyticum will …