[HTML][HTML] PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling
Y Liu, ELH Lui, SL Friedman, L Li, T Ye, Y Chen… - Laboratory …, 2009 - Elsevier
Liver fibrosis due to hepatic stellate cell (HSC) activation represents a common response to
chronic liver injury. PTK787/ZK222584 (PTK/ZK) is a pan-VEGFR tyrosine kinase inhibitor.
The aim of this study was to examine the effect of PTK/ZK in liver fibrosis. In primary HSCs,
PTK/ZK inhibited the expression of α-smooth muscle actin (α-SMA), collagen, tissue inhibitor
of metalloproteinase-1 (TIMP-1), as well as cell proliferation, migration and actin filament
formation. PTK/ZK-induced apoptosis of HSCs, which was correlated with increased …
chronic liver injury. PTK787/ZK222584 (PTK/ZK) is a pan-VEGFR tyrosine kinase inhibitor.
The aim of this study was to examine the effect of PTK/ZK in liver fibrosis. In primary HSCs,
PTK/ZK inhibited the expression of α-smooth muscle actin (α-SMA), collagen, tissue inhibitor
of metalloproteinase-1 (TIMP-1), as well as cell proliferation, migration and actin filament
formation. PTK/ZK-induced apoptosis of HSCs, which was correlated with increased …