Expression of plasminogen activator inhibitor-1 in human adipose tissue: a role for TNF-α?
M Cigolini, M Tonoli, L Borgato, L Frigotto, F Manzato… - Atherosclerosis, 1999 - Elsevier
Elevated plasminogen activator inhibitor-1 (PAI-1) plasma levels, responsible for reduced
fibrinolysis, are associated with animal and human obesity and with increased
cardiovascular disease. The expression of PAI-1 has been found recently in animal and
human adipose tissue. Factors and mechanisms regulating such an expression remain to be
elucidated. In omental and/or subcutaneous biopsies from obese non-diabetic patients,
incubated in Medium 199, we have confirmed that human adipose tissue expresses PAI-1 …
fibrinolysis, are associated with animal and human obesity and with increased
cardiovascular disease. The expression of PAI-1 has been found recently in animal and
human adipose tissue. Factors and mechanisms regulating such an expression remain to be
elucidated. In omental and/or subcutaneous biopsies from obese non-diabetic patients,
incubated in Medium 199, we have confirmed that human adipose tissue expresses PAI-1 …