STAT5A regulates DNMT3A in CD34+/CD38− AML cells
A Takeuchi, C Nishioka, T Ikezoe, J Yang… - Leukemia research, 2015 - Elsevier
Signal transducer and activator of transcription 5 (STAT5) is activated in CD34+/CD38−
acute myelogenous leukemia (AML) cells. Inhibition of STAT5 induced apoptosis and
sensitized these cells to the growth inhibition mediated by conventional chemotherapeutic
agents. The present study attempted to identify molecules that are regulated by STAT5 in
CD34+/CD38− AML cells by utilizing cDNA microarrays, comparing the gene expression
profiles of control and STAT5A shRNA-transduced CD34+/CD38− AML cells. Interestingly …
acute myelogenous leukemia (AML) cells. Inhibition of STAT5 induced apoptosis and
sensitized these cells to the growth inhibition mediated by conventional chemotherapeutic
agents. The present study attempted to identify molecules that are regulated by STAT5 in
CD34+/CD38− AML cells by utilizing cDNA microarrays, comparing the gene expression
profiles of control and STAT5A shRNA-transduced CD34+/CD38− AML cells. Interestingly …