CSF3R T618I, ASXL1 G942 fs and STAT5B N642H trimutation co-contribute to a rare chronic neutrophilic leukaemia manifested by rapidly progressive leucocytosis …
Q Luo, J Shen, Y Yang, H Tang, M Shi… - British journal of …, 2018 - search.ebscohost.com
Q Luo, J Shen, Y Yang, H Tang, M Shi, J Liu, Z Liu, X Shi, Y Yi
British journal of haematology, 2018•search.ebscohost.comThe article presents a case study of a 52-year-old woman who was diagnosed with chronic
neutrophilic leukaemia (CNL). Results of her complete blood count, peripheral blood smear,
bone marrow aspiration and cytogenetic analyses are discussed. The authors suggest that
CSF3R T618I, ASXL1 G942 fs and STAT5B N642H trimutation co-contribute to a rare CNL
manifested by rapidly progressive leucocytosis, severe infections, persistent fever and deep
venous thrombosis.
neutrophilic leukaemia (CNL). Results of her complete blood count, peripheral blood smear,
bone marrow aspiration and cytogenetic analyses are discussed. The authors suggest that
CSF3R T618I, ASXL1 G942 fs and STAT5B N642H trimutation co-contribute to a rare CNL
manifested by rapidly progressive leucocytosis, severe infections, persistent fever and deep
venous thrombosis.
Abstract
The article presents a case study of a 52-year-old woman who was diagnosed with chronic neutrophilic leukaemia (CNL). Results of her complete blood count, peripheral blood smear, bone marrow aspiration and cytogenetic analyses are discussed. The authors suggest that CSF3R T618I, ASXL1 G942 fs and STAT5B N642H trimutation co-contribute to a rare CNL manifested by rapidly progressive leucocytosis, severe infections, persistent fever and deep venous thrombosis.
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