Effects of β-carbolines in animal models of anxiety
SE File, HA Baldwin - Brain research bulletin, 1987 - Elsevier
Animal models of anxiety can be classified into three main groups: those based on conflict or
conditioned fear; those exploiting the anxiety produced by novelty; those in which anxiety or
aversion is chemically induced. This review briefly describes the existing tests and, where
available, the results obtained with β-carbolines. Many of the β-carbolines are anxiogenic in
the tests, however ZK 91296 and ZK 93423 appear to have anxiolytic properties, and ZK
93426 has a similar profile to that of the benzodiazepine receptor antagonist RO 15-1788 …
conditioned fear; those exploiting the anxiety produced by novelty; those in which anxiety or
aversion is chemically induced. This review briefly describes the existing tests and, where
available, the results obtained with β-carbolines. Many of the β-carbolines are anxiogenic in
the tests, however ZK 91296 and ZK 93423 appear to have anxiolytic properties, and ZK
93426 has a similar profile to that of the benzodiazepine receptor antagonist RO 15-1788 …