Morphologic and clinical significance of multifocal prostate cancers in radical prostatectomy specimens

AM Wise, TA Stamey, JE McNeal, JL Clayton - Urology, 2002 - Elsevier
Objectives. To examine the histologic details of small, independent cancers compared with
the largest (index) tumor and their impact on prostate-specific antigen (PSA) failure in 486
men treated only by radical retropubic prostatectomy (RRP). Methods. The tumor volume
and percentage of Gleason grade 4/5 carcinoma were recorded in 3-mm step sections.
Univariate statistics were calculated for the largest, total (largest plus smaller cancers), and
smaller tumor volumes, number of independent foci, patient age, and follow-up. Cox hazards …