Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

P Mombaerts, AR Clarke, MA Rudnicki, J Iacomini… - Nature, 1992 - nature.com
P Mombaerts, AR Clarke, MA Rudnicki, J Iacomini, S Itohara, JJ Lafaille, L Wang, Y Ichikawa…
Nature, 1992nature.com
Abstract Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that
TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8−
thymocytes to CD4+ CD8+ thymocytes, as well as for the expansion of the pool of CD4+
CD8+ cells. TCR-α is irrelevant in these developmental processes. The development of γδ T
cells does not depend on either TCR-α or TCP-β.
Abstract
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4 CD8 thymocytes to CD4+CD8+ thymocytes, as well as for the expansion of the pool of CD4+CD8+ cells. TCR-α is irrelevant in these developmental processes. The development of γδ T cells does not depend on either TCR-α or TCP-β.
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