Morphologic characterization of hamartomatous gastrointestinal polyps in Cowden syndrome, Peutz-Jeghers syndrome, and juvenile polyposis syndrome

R Shaco-Levy, KW Jasperson, K Martin, NJ Samadder… - Human pathology, 2016 - Elsevier
The morphologic features of the gastrointestinal polyps in hamartomatous polyposis
syndromes are poorly defined. Our aim was to better characterize the gastrointestinal
hamartomas in these syndromes. A blinded review was performed regarding many
histologic features for every polyp. The study included 15 Cowden syndrome, 13 Peutz-
Jeghers (PJS), 12 juvenile polyposis (JuvPS) patients, and 32 cases of sporadic
hamartomatous polyps. A total of 375 polyps were examined. Cowden syndrome polyps …