[HTML][HTML] The human recombinant histamine releasing factor: functional evidence that it does not bind to the IgE molecule
F Wantke, DW MacGlashan, JM Langdon… - Journal of allergy and …, 1999 - Elsevier
Background: We have previously shown that the human recombinant histamine releasing
factor (HrHRF) caused histamine release from a subset of basophils from donors with
allergy, and this release seemed to be dependent on the presence of a certain type of IgE,
termed IgE+. IgE molecules that did not support HrHRF-induced histamine release were
termed IgE–. However, subsequently we demonstrated that HrHRF primes anti-IgE-antibody–
induced histamine release from all basophils, irrespective of the type of IgE on the cell …
factor (HrHRF) caused histamine release from a subset of basophils from donors with
allergy, and this release seemed to be dependent on the presence of a certain type of IgE,
termed IgE+. IgE molecules that did not support HrHRF-induced histamine release were
termed IgE–. However, subsequently we demonstrated that HrHRF primes anti-IgE-antibody–
induced histamine release from all basophils, irrespective of the type of IgE on the cell …