[HTML][HTML] Pathogenesis and heterogeneity of ovarian cancer
PT Kroeger Jr, R Drapkin - Current Opinion in Obstetrics and …, 2017 - journals.lww.com
PT Kroeger Jr, R Drapkin
Current Opinion in Obstetrics and Gynecology, 2017•journals.lww.comThe fallopian tube secretory cell is the cell of origin for the majority of ovarian cancers.
Although it remains unclear what triggers neoplastic transformation of these cells, certain
tumors exhibit loss of BRCA function or amplification of CCNE1. These alterations represent
unique therapeutic opportunities in ovarian cancer.
Although it remains unclear what triggers neoplastic transformation of these cells, certain
tumors exhibit loss of BRCA function or amplification of CCNE1. These alterations represent
unique therapeutic opportunities in ovarian cancer.
Summary
The fallopian tube secretory cell is the cell of origin for the majority of ovarian cancers. Although it remains unclear what triggers neoplastic transformation of these cells, certain tumors exhibit loss of BRCA function or amplification of CCNE1. These alterations represent unique therapeutic opportunities in ovarian cancer.
Lippincott Williams & Wilkins