[HTML][HTML] FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression
T Wang, X Pei, J Zhan, J Hu, Y Yu, H Zhang - FEBS letters, 2012 - Elsevier
T Wang, X Pei, J Zhan, J Hu, Y Yu, H Zhang
FEBS letters, 2012•ElsevierFERM family proteins have been known to play an important role in tumor progression.
FERM-domain containing protein 5 (FRMD5), a novel putative cytoskeletal protein, is an
unknown function protein. Here, we reported that FRMD5 localized at the cell adherens
junction and formed a molecular complex with p120-catenin through its C-terminal region.
Functionally, we found that knockdown of endogenous FRMD5 promotes lung cancer cell
migration and invasion in vitro as well as tumor growth in vivo, suggesting a tumor …
FERM-domain containing protein 5 (FRMD5), a novel putative cytoskeletal protein, is an
unknown function protein. Here, we reported that FRMD5 localized at the cell adherens
junction and formed a molecular complex with p120-catenin through its C-terminal region.
Functionally, we found that knockdown of endogenous FRMD5 promotes lung cancer cell
migration and invasion in vitro as well as tumor growth in vivo, suggesting a tumor …
FERM family proteins have been known to play an important role in tumor progression. FERM-domain containing protein 5 (FRMD5), a novel putative cytoskeletal protein, is an unknown function protein. Here, we reported that FRMD5 localized at the cell adherens junction and formed a molecular complex with p120-catenin through its C-terminal region. Functionally, we found that knockdown of endogenous FRMD5 promotes lung cancer cell migration and invasion in vitro as well as tumor growth in vivo, suggesting a tumor suppressive effect. These findings indicated that FRMD5 may play a role in p120-catenin-based cell–cell contact and is involved in the regulation of tumor progression. STRUCTURED SUMMARY OF PROTEIN INTERACTIONS: FRMD5 and p120 catenincolocalize by fluorescence microscopy (View interaction) FRMD5physically interacts with p120 catenin by anti tag coimmunoprecipitation (View interaction) FRMD5 and Beta-catenincolocalize by fluorescence microscopy (View interaction) FRMD5 and gamma-catenincolocalize by fluorescence microscopy (View interaction) FRMD5physically interacts with p120 catenin and E cadherin by anti bait coimmunoprecipitation (View interaction)
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