Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis
Background Exposure to food allergens through a disrupted skin barrier has been
recognized as a potential factor in the increasing prevalence of food allergy. Objective We
sought to test the immunologic mechanisms by which epicutaneous sensitization to food
allergens predisposes to intestinal food allergy. Methods Mice were epicutaneously
sensitized with ovalbumin or peanut on an atopic dermatitis–like skin lesion, followed by
intragastric antigen challenge. Antigen-specific serum IgE levels and TH 2 cytokine …
recognized as a potential factor in the increasing prevalence of food allergy. Objective We
sought to test the immunologic mechanisms by which epicutaneous sensitization to food
allergens predisposes to intestinal food allergy. Methods Mice were epicutaneously
sensitized with ovalbumin or peanut on an atopic dermatitis–like skin lesion, followed by
intragastric antigen challenge. Antigen-specific serum IgE levels and TH 2 cytokine …