Objectives

The aim of this meta-analysis was to estimate the association between the FCGR2A rs1801274 polymorphism and the susceptibility to autoimmune diseases more precisely.

Methods

A meta-analysis was conducted on the association between the FCGR2A gene variants and ADs by allelic contrast, homozygote contrast, the recessive model, and the dominant model.

Results

A total of 17 studies with 30 comparisons in different populations and genotype-methods were available for this meta-analysis, including 10 Kawasaki disease (KD), 7 Ulcerative colitis (UC), 6 Crohn's disease (CD), 3 Rheumatoid arthritis (RA), 2 Systemic lupus erythematosus (SLE), 1 Autoimmune thyroid disease (ATD) and 1 diabetes mellitus type 1 (T1D). A significant association between FCGR2A rs1801274 polymorphism were found in KD (OR= 1.409, P< 0.001) and UC (OR= 1.237, P< 0.001). A overall meta-analysis increased risk of AD significant association between FCGR2A rs1801274 gene polymorphism and ADs under allelic (OR= 1.378, P= 0.000), homozygous (OR: 1.866, P= 0.001), dominant (OR= 1.667, P= 0.000) and recessive (OR= 1.434, P= 0.000) in Asian population. Meanwhile, a decreased risk of AD was detected in the allelic (OR= 0.882, P= 0.011), homozygous (OR= 0.777, P= 0.013), dominant (OR= 0.850, P= 0.032) and recessive (OR= 0.840, P= 0.048) in African-American population.

Conclusions

This meta-analysis demonstrates that the FCGR2A rs1801274 G-allele confers susceptibility to KD and UC. Data also suggests that the FCGR2A rs1801274 polymorphism may be associated with the susceptibility of multiple ADs in Asian and African-American populations.