Advanced age is an independent risk factor for ageing-related complex diseases, such as
coronary artery disease, stroke, and hypertension, which are common but life threatening
and related to the ageing-associated vascular dysfunction. On the other hand, patients with
progeria syndromes suffer from serious atherosclerosis, suggesting that the impaired
vascular functions may be critical to organismal ageing, or vice versa. However, it remains
largely unknown how vascular cells, particularly endothelial cell, become senescent and …