Although hematopoietic stem cells (HSCs) have traditionally been thought to possess the
ability to give rise to all the mature cell types in the hematopoietic system, this conception of
hematopoiesis was based on evaluation of hematopoietic output from large numbers of
HSCs using transplantation models. More recent studies evaluating HSCs at the clonal or
near-clonal level, both in transplantation studies and during in situ hematopoiesis, have
established that individual HSCs can exhibit lineage bias, giving rise to myeloid-biased …